PCORI Broad Pragmatic Studies — Cycle 2, 2026
PCORI has opened Cycle 2 of its Broad Pragmatic Studies funding announcement, one of the largest mechanisms for patient-centered comparative effectiveness research. Pragmatic studies using observational data infrastructure like OMOP are squarely in scope.
LOI Deadline: April 1, 2026 | Application Deadline: April 28, 2026
Opportunity details
LOI Deadline: April 1, 2026 Application Deadline: April 28, 2026 Type: Research — Comparative Effectiveness Status: Open
This mechanism funds large-scale pragmatic studies that compare healthcare interventions in real-world settings. OMOP-based infrastructure is a strong foundation for proposals — standardized data across sites, reproducible cohort definitions, and established analytics tooling.
Related PCORI opportunities (same cycle)
- Phased Large Awards for CER — LOI April 1
- Improving Methods for CER — LOI April 1
- Sensory Health Across the Lifespan — LOI April 1